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. 2017 Oct 4;17:86. doi: 10.1186/s12935-017-0457-z

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Dual EGFR and BRAF blockade inhibits cell proliferation and cell cycle progression in BRAF V600E thyroid carcinoma cells. a, b Cell growth (a) and cell cycle distribution (b) in BRAF V600E FRO, BCPAP and BHT101 thyroid carcinoma cell lines exposed to 1–10 μM PLX4032 or 1–10 μM gefitinib or the combination of both agents for indicated time points. Cell cycle distribution was evaluated after 24 h treatment. Statistical significance respect to vemurafenib single agent: *p < 0.05; **p < 0.005; ***p < 0.0005