Fig. 1.

Expression of miR-216b showed an opposite trend against FOXM1 level in cervical cancer cells and was down-regulated in cervical cancer tissues. a Western blotting analysis showed FOXM1 expression levels were significantly elevated in cervical cancer cell lines HeLa, SiHa, Ca Ski, C33A and HCC94. Control was normal cervical tissue from patients underwent hysterectomy because of uterine leiomyomata. * P < 0.05. b Real-time PCR analysis of miR-216b expression in cervical cancer cell lines (HeLa, SiHa, Ca Ski, C33A and HCC94) showed an opposite trend compared to FOXM1. The average miR-216b expression was normalized using U6 expression. Control was tissue from normal cervix. * P < 0.05. c Relative T/ANT ratio showed miR-216b level was decreased in cervical cancer tissues than adjacent non-cancer tissues. The expression of miR-216b was examined in 8 paired cervical cancer tissues (T) and their adjacent non-cancer tissues (ANT). Relative T/ANT ratio was shown