Table 3.
Comparison of erosion volume and bone parameters by high-resolution peripheral quantitative computed tomography between baseline and 3 months in each treatment group
| Total (n = 19) | MTX-only group (n = 9) | MTX + anti-TNFα group (n = 13) | ||||||
|---|---|---|---|---|---|---|---|---|
| Mean ± SD | Baseline | 3 Months | Changes (A) | p value* | Baseline | 3 Months | Changes (A) | p value* |
| MCP2 | ||||||||
| Erosion number (n) | 7 | 7 | 23 | 23 | ||||
| Erosion volume (mm3) | 6.7 ± 6.4 | 7.5 ± 6.4 | 0.9 ± 0.5 | 0.006 | 41.4 ± 65.5 | 37.6 ± 60.3 | -3.8 ± 5.2 | 0.048 |
| Joint space | ||||||||
| Width (mm) | 1.81 ± 0.14 | 1.80 ± 0.13 | -0.01 ± 0.07 | 0.705 | 1.87 ± 0.20 | 1.80 ± 0.15 | -0.07 ± 0.09 | 0.028 |
| Volume (mm3) | 133.6 ± 17.3 | 134.6 ± 16.0 | 1.0 ± 5.5 | 0.606 | 125.4 ± 20.5 | 118.7 ± 17.0 | -6.68 ± 7.08 | 0.001 |
| MCH2 microarchitecture BMD (mg/cm3) | ||||||||
| Total | 279.9 ± 34.2 | 277.4 ± 40.2 | -6.2 ± 16.1 | 0.288 | 316.2 ± 34.7 | 327.8 ± 45.9 | 11.6 ± 33.0 | 0.268 |
| Trabecular | 236.2 ± 26.9 | 233.6 ± 33.2 | -2.6 ± 20.4 | 0.731 | 259.0 ± 25.6 | 266.9 ± 41.0 | 7.8 ± 26.8 | 0.353 |
| MCP3 | ||||||||
| Erosion number (n) | 4 | 4 | 13 | 13 | ||||
| Erosion volume (mm3) | 2.3 ± 11.5 | 3.1 ± 1.2 | 0.8 ± 0.5 | 0.019 | 21.6 ± 31.5 | 18.9 ± 29.0 | -2.7 ± 2.5 | 0.014 |
| Joint space | ||||||||
| Width (mm) | 1.72 ± 0.14 | 1.74 ± 0.15 | 0.02 ± 0.05 | 0.226 | 1.83 ± 0.12 | 1.74 ± 0.14 | -0.10 ± 0.07 | 0.001 |
| Volume (mm3) | 138.9 ± 17.0 | 142.1 ± 20.2 | 3.2 ± 4.3 | 0.069 | 131.9 ± 24.1 | 125.6 ± 21.4 | -4.3 ± 4.6 | 0.003 |
| MCH3 microarchitecture BMD (mg/cm3) | ||||||||
| Total | 279.9 ± 28.0 | 280.8 ± 25.0 | 1.0 ± 7.0 | 0.706 | 324.5 ± 35.7 | 321.8 ± 34.8 | -2.7 ± 8.4 | 0.298 |
| Trabecular | 238.9 ± 20.1 | 241.9 ± 18.1 | 3.0 ± 8.1 | 0.322 | 269.4 ± 26.7 | 267.6 ± 26.1 | -1.7 ± 8.5 | 0.513 |
| Distal radius | ||||||||
| Erosion number (n) | 15 | 15 | 11 | 11 | ||||
| Erosion volume (mm3) | 21.1 ± 26.4 | 23.4 ± 29.1 | 1.6 ± 3.3 | 0.075 | 199.9 ± 362.6 | 188.4 ± 331.4 | -15.5 ± 31.7 | 0.211 |
| Joint space | ||||||||
| Width (mm3) | 2.04 ± 0.24 | 2.04 ± 0.18 | -0.01 ± 0.12 | 0.981 | 2.09 ± 0.29 | 2.11 ± 0.29 | 0.01 ± 0.17 | 0.758 |
| Volume (mm3) | 249.8 ± 29.3 | 261.1 ± 30.5 | 11.3 ± 22.3 | 0.197 | 247.5 ± 67.1 | 240.2 ± 71.2 | -7.3 ± 25.0 | 0.356 |
| Wrist microarchitecture BMD (mg/cm3) | ||||||||
| Total | 272.3 ± 61.3 | 272.8 ± 60.3 | 0.6 ± 4.3 | 0.709 | 356.0 ± 58.6 | 354.0 ± 58.4 | -2.0 ± 7.1 | 0.357 |
| Cortical | 793.7 ± 82.9 | 792.1 ± 83.2 | -1.6 ± 9.8 | 0.663 | 873.4 ± 42.7 | 874.9 ± 43.7 | 1.5 ± 9.7 | 0.607 |
| Trabecular | 148.0 ± 31.0 | 148.6 ± 30.8 | 0.6 ± 2.7 | 0.543 | 174.5 ± 53.7 | 172.0 ± 51.2 | -2.5 ± 5.1 | 0.115 |
| Cortical thickness (μm) | 607.8 ± 200.4 | 606.7 ± 199.5 | 3.8 ± 21.2 | 0.900 | 824.6 ± 142.7 | 830.8 ± 140.8 | 6.2 ± 27.3 | 0.450 |
| Trabecular | ||||||||
| Number | 1.82 ± 0.14 | 1.80 ± 0.17 | -0.02 ± 0.15 | 0.748 | 1.97 ± 0.45 | 1.94 ± 0.42 | -0.03 ± 0.10 | 0.315 |
| Thickness (μm) | 68.9 ± 12.6 | 69.9 ± 12.6 | 1.4 ± 5.0 | 0.441 | 72.9 ± 10.8 | 73.1 ± 10.2 | 0.2 ± 4.1 | 0.898 |
| Separation (μm) | 485.7 ± 51.1 | 491.2 ± 60.0 | 5.6 ± 45.6 | 0.740 | 471.5 ± 171.7 | 475.1 ± 156.3 | 3.6 ± 34.8 | 0.725 |
The distal radius joint space was measured at the radio-lunar joint. MTX methotrexate, TNFa tumor necrosis factor alpha, MCH metacarpal heads, BMD bone mineral density. *Paired t test. Bold characters mean p < 0.05