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Simplified scheme of the coagulation cascade: Extrinsic (initimal injury) and intrinsic (contact activation) pathways involved in the formation of crosslinked fibrin. TFPI inhibits factor VIIa-related activation of factor Xa. Antithrombin degrades thrombin and factor Xa. Protein C and its co-enzyme protein S degrade the cofactors Va and VIIIa. HMWK, high molecular weight kininogen; PK, prekallikrein; TFPI, tissue factor pathway inhibitor
