TABLE 3.

Changes in Coagulation Cascade During Pregnancy

		Humans	Rats, mice	Rabbits	References
Coagulation	Factor I	↑	↑	↑	(Brenner, 2004, Lockwood, 2006, Urasoko et al., 2009, Szecsi et al., 2010, Mizoguchi et al., 2010, Liu et al., 2012, Urasoko et al., 2012)
	Factor II	↑/=	↑		(Brenner, 2004, Lockwood, 2006, Tchaikovski et al., 2009, Szecsi et al., 2010, Liu et al., 2012, Urasoko et al., 2012)
	Factor V	↓/=	↑		(Brenner, 2004, Lockwood, 2006, Tchaikovski et al., 2009, Szecsi et al., 2010, Liu et al., 2012)
	Factor X	↑/=	↑		(Brenner, 2004, Lockwood, 2006, Tchaikovski et al., 2009, Szecsi et al., 2010, Liu et al., 2012)
Anticoagulation	Antithrombin	=/↓	=/↑	↑	(Brenner, 2004, Lockwood, 2006, Tchaikovski et al., 2009, Urasoko et al., 2009, Szecsi et al., 2010, Mizoguchi et al., 2010, Haneda et al., 2010, Liu et al., 2012, Urasoko et al., 2012)
	Protein S	↓	↑		(Brenner, 2004, Lockwood, 2006, Tchaikovski et al., 2009, Szecsi et al., 2010, Liu et al., 2012)
	TFPI	↓	↑		(Brenner, 2004, Lockwood, 2006, Tchaikovski et al., 2009, Szecsi et al., 2010, Liu et al., 2012)
Common coagulation assays	PT	=/↓	↓	↓	(Brenner, 2004, Lockwood, 2006, Urasoko et al., 2009, Szecsi et al., 2010, Mizoguchi et al., 2010, Liu et al., 2012, Urasoko et al., 2012)
	APC resistance	↑	↓		(Brenner, 2004, Lockwood, 2006, Tchaikovski et al., 2009, Szecsi et al., 2010, Liu et al., 2012)

Abbreviations: APC, activated protein C; PT, prothrombin time; TFPI, tissue factor pathway inhibitor.

↑, increase; ↓, decrease; =no change in the coagulation parameters during pregnancy.