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. 2017 Aug 1;2(1):224–234. doi: 10.1089/can.2017.0022

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© Matthew F. Lazenka et al. 2017; Published by Mary Ann Liebert, Inc.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 3. — Cdk5 expression increased in the PFC after repeated THC administration. Graphs show Cdk5 protein after acute vehicle or THC challenge in repeated vehicle- or THC-treated mice expressed as percentage Cdk5 expression in VEH-VEH mice in (A) PFC, (B) NAc, (C) CPu, and (D) Amyg. (A) Significant main effect of repeated treatment [F(1,25)=29.79, p<0.001] and main effect of acute treatment [F(1,25)=4.67, p<0.05] in PFC. Significance was determined with two-way ANOVA and Dunnett's post hoc test. *p<0.05, ***p<0.001 compared with VEH-VEH-treated mice. Data are presented as mean±SEM from N=5–8 mice per treatment group. Cdk5, cyclin-dependent kinase 5.