Table 1.

Combination index (CI) and fractional effect (FE) values (mean (±SD)) of simvastatin/tipifarnib cotreatments in human leukemia cell lines.

Cell line Tipifarnib (μM)/Simvastatin (μM)	KG1		HL60		K562		Jurkat		Molt4		HSB2
	CI	FE	CI	FE	CI	FE	CI	FE	CI	FE	CI	FE
0.05/1	0.586 (±0.246)	0.271 (±0.053)	0.264 (±0.085)	0.408 (±0.015)	0.267 (±0.159)	0.412 (±0.129)	0.367 (±0.151)	0.287 (±0.125)	0.263 (±0.114)	0.413 (±0.107)	0.413 (±0.313)	0.287 (±0.125)
0.1/1	1.036 (±0.002)	0.270 (±0.101)	0.401 (±0.030)	0.418 (±0.003)	0.258 (±0.117)	0.474 (±0.085)	0.331 (±0.023)	0.317 (±0.026)	0.331 (±0.123)	0.384 (±0.123)	0.331 (±0.269)	0.317 (±0.026)
0.5/1	1.414 (±0.254)	0.401 (±0.060)	0.564 (±0.184)	0.536 (±0.031)	0.422 (±0.166)	0.568 (±0.080)	0.561 (±0.064)	0.412 (±0.042)	0.427 (±0.083)	0.536 (±0.085)	0.484 (±0.289)	0.412 (±0.042)
1/1	0.970 (±0.123)	0.494 (±0.050)	0.613 (±0.181)	0.609 (±0.059)	0.580 (±0.144)	0.596 (±0.047)	0.700 (±0.080)	0.492 (±0.073)	0.391 (±0.134)	0.692 (±0.113)	0.545 (±0.319)	0.492 (±0.073)
0.05/4	1.051 (±0.298)	0.256 (±0.122)	0.185 (±0.043)	0.745 (±0.045)	0.436 (±0.222)	0.596 (±0.064)	0.606 (±0.268)	0.487 (±0.149)	0.520 (±0.251)	0.503 (±0.085)	0.401 (±0.257)	0.350 (±0.054)
0.1/4	0.491 (±0.058)	0.395 (±0.065)	0.177 (±0.044)	0.771 (±0.052)	0.427 (±0.223)	0.626 (±0.059)	0.664 (±0.194)	0.578 (±0.149)	0.584 (±0.103)	0.492 (±0.031)	0.505 (±0.217)	0.364 (±0.049)
0.5/4	0.677 (±0.016)	0.478 (±0.048)	0.190 (±0.037)	0.828 (±0.044)	0.508 (±0.160)	0.673 (±0.032)	0.640 (±0.227)	0.611 (±0.114)	0.519 (±0.182)	0.628 (±0.072)	0.441 (±0.297)	0.494 (±0.098)
1/4	1.208 (±0.061)	0.517 (±0.006)	0.225 (±0.029)	0.854 (±0.040)	0.612 (±0.250)	0.698 (±0.040)	0.753 (±0.310)	0.646 (±0.091)	0.600 (±0.274)	0.680 (±0.111)	0.544 (±0.306)	0.534 (±0.142)