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. 2017 May 10;16(19):1790–1799. doi: 10.1080/15384101.2017.1325046

Figure 3.

Figure 3.

ONC212 and ONC206 downstream mechanism of action is similar to ONC201. A) CHOP and B) DR5 Gene expression data from ONC201, ONC206, and ONC212 treated in HCT116 cells over time relative to GAPDH and Vehicle. C) ONC201, ONC212, and ONC206 TRAIL surface expression analysis at indicated time points in HCT116 and TRAIL-resistant HCT116-Bax−/−. D) Western blot analysis results of HCT116 cells treated with ONC201 and ONC212 treated overtime. E) Quantitation of western blots (ONC201: 10 μM; ONC212: 0.01 μM; ONC206: 0.05 μM). N = 3; Western blot representative of 3 biological replicates.