Table 1.

Association of the frequency of methylation occurrence of PAX1 and SOX1 in cancer tissues to the clinical characteristics of 41 patients with CRC

Characteristics	N	SOX1				PAX1
		M	U	Methylation percentage	P-value*	M	U	Methylation percentage	P-value*
Age, years					0.460				0.460
Mean (SD) [range]	56	(12.65)	(27–84)
<60	25	16	9	64.00		16	9	64.00
>60	16	12	4	75.00		12	4	75.00
Gender					0.658				0.025
Male	20	13	7	65.00		17	3	85.00
Female	21	15	6	71.43		11	10	52.38
Tumor location					0.987				0.987
Colon	19	13	6	68.42		13	6	68.42
Rectum	22	15	7	68.18		15	7	68.18
LN metastasis					0.203				0.072
N0	29	19	10	65.52		18	11	62.07
N1	11	9	2	81.82		10	1	90.91
N2	1	0	1	0.00		0	1	0.00
Tumor invasion					0.548				0.661
T1	3	3	0	100.00		3	0	100.00
T2	12	8	4	66.67		8	4	66.67
T3	5	4	1	80.00		3	2	60.00
T4	21	13	8	61.90		14	7	66.67
TNM stage					0.666				0.646
I	9	7	2	77.78		7	2	77.78
II	18	9	9	50.00		9	9	50.00
III	12	10	2	83.33		10	2	83.33
IV	2	2	0	100.00		2	0	100.00
Tumor HG					0.432				0.432
Poor	7	6	1	85.71		6	1	85.71
Moderate	20	12	8	60.00		12	8	60.00
Well	14	10	4	71.43		10	4	71.43
Tumor size					0.063				0.128
<3 cm	3	0	3	0.00		1	2	33.33
3–5 cm	9	6	3	66.67		4	5	44.44
>5 cm	5	4	1	80.00		4	1	80.00
NA	24	18	6	75.00		19	5	79.17

Note:

^*Calculated by χ² test.

Abbreviations: CRC, colorectal cancer; HG, histological grade; LN, lymph node; M, methylated; PAX1, paired boxed gene 1; SOX1, sex-determining region Y-related high-mobility group box 1; U, unmethylated.