Table 4.
Correlation between methylation levels of PAX1 and SOX1 in the cancer tissues and clinical characteristics of 41 patients with CRC
| Characteristics |
PAX1 methylation level
|
SOX1 methylation level
|
||
|---|---|---|---|---|
| Mean ± SD | P-value* | Mean ± SD | P-value* | |
| Age, years | 0.621 | 0.779 | ||
| <60 | 1.59±3.10 | 1.94±2.83 | ||
| >60 | 2.37±2.53 | 2.46±2.69 | ||
| Gender | 0.050 | 0.531 | ||
| Male | 2.92±2.07 | 2.00±2.79 | ||
| Female | 0.92±3.24 | 2.28±2.78 | ||
| Tumor location | 0.296 | 0.143 | ||
| Colon | 2.17±2.77 | 2.33±2.66 | ||
| Rectum | 1.66±3.02 | 1.98±2.89 | ||
| TNM stage | 0.007 | 0.046 | ||
| I/II | 1.26±2.94 | 1.77±2.88 | ||
| III/IV | 3.11±2.43 | 2.87±2.43 | ||
| Tumor size | 0.399 | 0.792 | ||
| <5 cm | 0.19±3.37 | 1.09±3.14 | ||
| >5 cm | 2.60±2.90 | 2.57±2.84 | ||
| Tumor HG | 0.273 | 0.080 | ||
| W/M | 1.52±2.99 | 1.86±2.82 | ||
| Poor | 3.39±1.93 | 3.21±2.41 | ||
| Tumor invasion | 0.665 | 0.807 | ||
| T1/2 | 1.92±2.85 | 2.41±2.70 | ||
| T3/4 | 1.89±2.96 | 1.99±2.83 | ||
| LN metastasis | 0.071 | 0.192 | ||
| N0 | 1.46±2.93 | 1.94±2.85 | ||
| N1/2/3 | 2.93±2.60 | 2.65±2.56 | ||
Notes:
*
Association analysis for methylation status by Mann–Whitney U-test. Significant values <0.05 were shown in bold font.
Abbreviations: CRC, colorectal carcinoma; LN, lymph node; HG, histological grade; PAX1, paired boxed gene 1; SOX1, sex-determining region Y-related high-mobility group box 1; W/M, well/moderate.