. 2017 Sep 21;17(12):1–124.

Table 18:

Clinical Outcome Parameters Used in the Economic Model

Variable	Outcome (Base Case)	Range	Reference^a
Total Contact Casting
Probability of ulcer healing	0.741	0.677–0.915	Meta-analysis^{16,28,29,32–36,38,39}
Time to healing, weeks	5.097	3.823–6.371	Meta-analysis^{16,28,29,33–35,38,39}
Probability of amputation from an unhealed ulcer	0.0092	0.0065–0.0153	CDA⁴⁵
Removable Cast Walkers
Risk ratio of ulcer healing (total contact casting vs. removable cast walkers)	1.25	0.95–1.65	Meta-analysis^32–34,38
Probability of ulcer healing	0.593	0.449–0.779	Calculation
Mean difference in time to healing (total contact casting vs. removable cast walkers), weeks	–1.013	–1.816 to −0.209	Meta-analysis^32–34,38
Time to healing, weeks	6.11	5.31–6.12	Calculation
Probability of amputation from an unhealed ulcer	0.0145	0.0102–0.0240	CDA⁴⁵
Irremovable Cast Walkers
Risk ratio of ulcer healing (total contact casting vs. irremovable cast walkers)	1.02	0.87–1.19	Meta-analysis^28,29,36
Probability of ulcer healing	0.726	0.623–0.852	Calculation
Mean difference in time to healing (total contact casting vs. irremovable cast walkers), weeks	–0.329	–1.59 to 0.939	Meta-analysis^28,29,36
Time to healing, weeks	5.425	4.164–6.687	Calculation
Probability of amputation from an unhealed ulcer	0.0097	0.0068–0.0161	CDA⁴⁵
Therapeutic Shoes
Risk ratio of ulcer healing (total contact casting vs. therapeutic shoes)	1.62	1.11–2.38	Meta-analysis^16,32,38,39
Probability of ulcer healing	0.457	0.311–0.667	Calculation
Mean difference in time to healing (total contact casting vs. therapeutic shoes), weeks	–3.73	–5.25 to −2.22	Meta-analysis^16,32,38,39
Time to healing, weeks	8.83	7.32–10.34	Calculation
Probability of amputation from an unhealed ulcer	0.0193	0.0136–0.0320	CDA⁴⁵

Abbreviation: CDA, Canadian Diabetes Association.

Meta-analysis included studies reported in the clinical evidence review.^{16,28,29,32–36,38,39}