Table 5.
Predictors of eGFR Changes | Univariate Model | Multivariable Model | ||
---|---|---|---|---|
β (95% CI) | P Value | β (95% CI) | P Value | |
Age, per 10 yr | −0.06 (−2.8 to 2.7) | 0.97 | 0.81 (−1.9 to 3.5) | 0.56 |
Sex, men versus women | 1.6 (−4.2 to 7.4) | 0.58 | −0.27 (−6.2 to 5.6) | 0.93 |
Race, white versus nonwhite | 2.6 (−2.6 to 7.9) | 0.32 | 0.54 (−4.7 to 5.8) | 0.84 |
Diabetes versus nondiabetic | −6.9 (−11 to −2.1) | <0.01 | −8.0 (−13 to −2.7) | 0.004 |
Cirrhosis versus noncirrhotic | −1.1 (−6.4 to 4.3) | 0.69 | −0.74 (−6.3 to 4.8) | 0.79 |
Hypertension versus normotensive | −3.9 (−11 to 3.3) | 0.29 | −3.3 (−10.7 to 4.1) | 0.37 |
Baseline eGFR, per 10-ml/min increase in eGFR | −0.05 (−3.1 to 3.0) | 0.97 | −1.5 (−4.8 to 1.7) | 0.34 |
Achieving sustained virologic response | 6.4 (−2.5 to 15.2) | 0.15 | 9.3 (0.44 to 18) | 0.04 |
Model constructed to predict change in eGFR in milliliters per minute from baseline to 6-month follow-up period. Post-treatment follow-up eGFR is missing from n=2 patients with baseline eGFR ≥60 ml/min per 1.73 m2 and n=1 patient with baseline eGFR <60 ml/min per 1.73 m2. 95% CI, 95% confidence interval.