Table 1. 20 responsive miRNAs with the greatest difference in expression levels in trastuzumab treated SKBR3 and BT474 cell lines.
| MicroRNA ID | Gmean BT474 Trastuzumab | Gmean BT474 PBS | Fold-change | p-value* |
| hsa-miR-34c-3p | 76.9 | 10 | 7.69 | 0.000495 |
| hsa-miR-588 | 85.79 | 14.4 | 5.96 | 0.001264 |
| hsa-miR-580 | 58.94 | 10 | 5.89 | 0.001384 |
| hsa-miR-374a-3p | 175.49 | 29.84 | 5.88 | 0.001392 |
| hsa-miR-616-3p | 62.19 | 10.83 | 5.74 | 0.001721 |
| hsa-miR-3124-3p | 166.41 | 29.76 | 5.59 | 0.002031 |
| hsa-miR-5088 | 307.06 | 56.29 | 5.46 | 0.002344 |
| hsa-miR-541-5p | 97.02 | 19.1 | 5.08 | 0.00259 |
| hsa-miR-493-3p | 83.25 | 16.82 | 4.95 | 0.002595 |
| hsa-miR-551b-5p | 83.11 | 17.34 | 4.79 | 0.002642 |
| hsa-miR-466 | 33.72 | 299.95 | -8.90 | 0.048349 |
| hsa-miR-5692a | 12.15 | 102.61 | -8.45 | 0.049597 |
| hsa-miR-99a-3p | 18.39 | 123.48 | -6.71 | 0.049275 |
| hsa-miR-379-3p | 29.91 | 200.03 | -6.69 | 0.049586 |
| hsa-miR-3671 | 11.07 | 62.79 | -5.67 | 0.048871 |
| hsa-miR-937-3p | 13.98 | 77.8 | -5.57 | 0.048947 |
| hsa-miR-876-5p | 16.9 | 89.68 | -5.31 | 0.048314 |
| hsa-miR-1228-5p | 17.77 | 90.27 | -5.08 | 0.048149 |
| hsa-miR-300 | 20.41 | 102.78 | -5.04 | 0.04733 |
| hsa-miR-6502-3p | 19.4 | 97.29 | -5.01 | 0.047564 |
| MicroRNA ID | Gmean SKBR3 Trastuzumab | Gmean SKBR3 PBS | Fold-change | p-value* |
| hsa-miR-580 | 185.53 | 11.47 | 16.18 | 0.003577 |
| hsa-miR-338-5p | 125.93 | 11.94 | 10.54 | 0.005305 |
| hsa-miR-5196-5p | 215.5 | 24.32 | 8.86 | 0.00041 |
| hsa-miR-4768-3p | 129.57 | 16.88 | 7.68 | 0.001565 |
| hsa-miR-92b-5p | 78.06 | 10.56 | 7.39 | 0.004378 |
| hsa-miR-4754 | 199.53 | 27.21 | 7.33 | 0.001553 |
| hsa-miR-890 | 67.76 | 10.02 | 6.76 | 0.004637 |
| hsa-miR-6716-5p | 97.1 | 15.48 | 6.27 | 0.008135 |
| hsa-miR-613 | 149.1 | 23.91 | 6.24 | 0.035063 |
| hsa-miR-5090 | 527.56 | 85.64 | 6.16 | 0.001562 |
| hsa-miR-200a-3p | 24.74 | 520.28 | -21.03 | 0.041457 |
| hsa-miR-339-3p | 43.85 | 763.4 | -17.41 | 0.004607 |
| hsa-miR-345-5p | 18.87 | 296.55 | -15.72 | 0.001076 |
| hsa-miR-19a-5p | 24.05 | 233.07 | -9.69 | 0.030978 |
| hsa-miR-4760-5p | 11.64 | 108.72 | -9.34 | 0.021372 |
| hsa-miR-3684 | 20.84 | 162.31 | -7.79 | 0.002313 |
| hsa-miR-190a | 34.15 | 254.61 | -7.46 | 0.043939 |
| hsa-miR-514a-5p | 20.39 | 139.41 | -6.84 | 0.001464 |
| hsa-miR-3976 | 25.61 | 161.05 | -6.29 | 0.028377 |
| hsa-miR-10b-5p | 39.53 | 239.88 | -6.07 | 0.008059 |
Gmean BT474 trastuzumab and BT474 PBS, Geometric mean values of signal intensities in trastuzumab and PBS treated BT474 cell lines; Gmean SKBR3 trastuzumab and SKBR3 PBS, Geometric mean values of signal intensities in trastuzumab and PBS treated SKBR3 cell lines
*p-values calculated using a two sample ttest (random variance model).