Table 3. Top 30 genes targeted by responsive miRNAs in trastuzumab treated BT474 and SKBR3 cells that were used for the functional validation.
| Gene ID | Gene Frequency in BT474* | Gene ID | Gene Frequency in SKBR3* |
|---|---|---|---|
| FAM9C | 19 | SAMD12 | 12 |
| SAMD12 | 16 | TFRC | 10 |
| UBE2W | 15 | ARL15 | 10 |
| CCDC38 | 13 | CLLU1 | 9 |
| MDM4 | 13 | CADM2 | 9 |
| CADM2 | 13 | LPP | 9 |
| KSR2 | 13 | PFN2 | 8 |
| CLLU1 | 13 | STC1 | 8 |
| INO80D | 13 | TMEM154 | 8 |
| TFRC | 12 | KLF12 | 8 |
| FZD3 | 12 | BTG1 | 8 |
| OSTN | 12 | C22ORF46 | 8 |
| CYP3A5 | 12 | RAB27B | 8 |
| LPP | 12 | GNG12 | 8 |
| FAM222B | 11 | IMPG1 | 8 |
| TMEM212 | 11 | REEP3 | 7 |
| GABRA4 | 11 | MLANA | 7 |
| PI15 | 11 | PI15 | 7 |
| BTLA | 11 | PRPF38A | 7 |
| ZFP36L1 | 11 | DST | 7 |
| GYPA | 11 | C9ORF170 | 7 |
| RAB30 | 11 | FAM9C | 7 |
| CHTF8 | 10 | YWHAG | 7 |
| EREG | 10 | CDK6 | 7 |
| ZNF286B | 10 | FAM169A | 7 |
| CYB561D1 | 10 | CPLX2 | 7 |
| ZNF676 | 10 | RAB3B | 7 |
| ZNF680 | 10 | S100A7A | 7 |
| C5ORF28 | 10 | C16ORF87 | 7 |
| GNG12 | 9 | TMEM170B | 7 |
* Gene frequency; total number of the potential miRNAs that might target the particular gene seen in the networks