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. 2017 Oct 5;12(10):e0185946. doi: 10.1371/journal.pone.0185946

Fig 1. Pigtailed macaque TAF2-ACV-ENG-EE pod-IVR study timelines and biological sample collection points (N = 6).

Fig 1

Configuration A pod-IVRs (rapid-releasing ENG) were inserted on Day 0 and replaced on Day 14 with Configuration B pod-IVRs (slow-releasing ENG). The Configuration B IVRs were removed on Day 30 and animals were euthanized on Day 34 (animal ID BB495 and DC42), Day 35 (animal ID PHz1 and PPk2), and Day 36 (animal ID PEc2 and BB0539). Blue arrows, in order of collection, blood, pH, and vaginal fluid (two Weck-Cel samples per time point—two proximal and two distal to the IVR). Green arrows, colposcopy examination (right after blood collection). Red arrows, vaginal tissues (six pinch biopsies per time point—three proximal and three distal to the IVR). Complete vaginal tracks were collected at necropsy. Pale blue and pale red arrows correspond to sample collection points with the IVR removed.