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. 2017 Oct 5;12(10):e0185940. doi: 10.1371/journal.pone.0185940

Fig 6. CD150 and CD180 are involved in regulation of Akt and MAPK pathways in CD150+CD180+ CLL cases.

Fig 6

(A) Kinetic of Akt, mTOR and their downstream targets phosphorylation after CD150, CD180 and simultaneous CD150 and CD180 ligation. (B) Kinetic of MAPK pathways activation after CD150, CD180 and simultaneous CD150 and CD180 crosslinking. Ligation of CD150 or CD180 alone led to activation both Akt and MAPK pathways. However, a combination of CD150 and CD180 ligation caused a block in both Akt and MAPK signaling. (C) Coligation of CD150 and CD40 did not inhibit Akt and MAPK pathways. The results represent one of three analyzed csCD150+CD180+ CLL cases. Western blot analysis.