Table 1.
Association of clinical features of early stage TSCC patients with MMP10 transcript and protein level expression.
| Clinicopathological features | MMP10 expression, number (%), along the column |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | N |
MMP10 transcript expression (n = 35) |
P value* | N | MMP10 protein expression (n = 43) |
P value* | |||
| Basal or Down | Up-regulated | Negative | Positive | ||||||
| Age | >45 years | 15 | 9 (41%) | 6 (46%) | 1 | 21 | 12 (50%) | 9 (47%) | 1 |
| <45 years | 20 | 13 (59%) | 7 (54%) | 22 | 12 (50%) | 10 (53%) | |||
| Gender | Male | 25 | 17 (77%) | 8 (62%) | 0.444 | 30 | 18 (75%) | 12 (63%) | 0.509 |
| Female | 10 | 5 (23%) | 5 (38%) | 13 | 6 (25%) | 7 (37%) | |||
| AJCC TNM stage | I–II | 13 | 7 (32%) | 6 (46%) | 0.48 | 16 | 8 (33%) | 8 (42%) | 0.752 |
| III–IVA | 22 | 15 (68%) | 7 (54%) | 27 | 16 (67%) | 11 (58%) | |||
| Node negative | 16 | 7 (54%) | 6 (46%) | 16 | 8 (34%) | 8 (42%) | |||
| Smoking | Smoker | 12 | 9 (41%) | 3 (23%) | 0.463 | 16 | 8 (33%) | 8 (42%) | 0.752 |
| Non-smoker | 23 | 13 (59%) | 10 (77%) | 27 | 16 (67%) | 11 (58%) | |||
| Alcohol | Yes | 8 | 5 (23%) | 3 (23%) | 1 | 14 | 8 (33%) | 6 (32%) | 1 |
| No | 27 | 17 (77%) | 10 (77%) | 29 | 16 (67%) | 13 (68%) | |||
| Tobacco | Yes | 24 | 18 (82%) | 6 (46%) | 0.057 | 28 | 14 (58%) | 14 (74%) | 0.349 |
| No | 11 | 4 (18%) | 7 (54%) | 15 | 10 (42%) | 5 (27%) | |||
N: Number of patients.
*
Chi-square t-test.