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Study protocol. We measured the the initial perception threshold (IPT) at 15, 30, 45, 60, 75, 90, 105, 120 minutes after corticotropin-releasing hormone (CRH) injection. IPT was measured 6 times before CRH injection. Then, baseline IPT was defined as the average of IPTs except for maximum and minimum IPTs. Blood was drawn and plasma adrenocorticotropic hormone and cortisol were measured at 0, 30, 60, 90, and 120 minutes after CRH injection. iv, intravenous.
