Table 2C. Treatment Regimen from Bilateral Wilms Tumor at Week 12.

BILATERAL WILMS TUMOR AFTER WEEK 12 IMAGING REVIEW
	REGIMEN
IF DEFINITIVE SURGERY HAD OCCURRED AT END OF WEEK 6	Continue with regimen as signed at the end of Week 6.
ATEND OF WEEK 6, THERAPY WAS EITHER CONTINUED CHEMOTHERAPY OR BILATERAL OPEN BIOPSIES WERE PERFORMED. DEFINITIVE SURGERY REQUIRED EITHER PARTIAL OR TOTAL NEPHRECTOMY (UNLESS CR BY IMAGING AT WEEK 12). Treatment will be based on the highest assigned risk for either kidney and systemic metastasis:
HISTOLOGY	STAGE	REGIMEN
	Complete response	DD-4A
Completely necrotic	I-II	EE-4A(
Completely necrotic	III-IV	DD-4A+XRT
Intermediate risk	I	EE-4A
Intermediate risk	II	DD-4A
Intermediate risk	III-IV	DD-4A+XRT
Blastemal predominant	I	DD-4A
Diffuse anaplastic Wilms tumor	I	DD-4A+XRT
Focal anaplastic Wilms tumor	I-III	DD-4A+XRT
Blastemal predominant	II	Reg. I
Blastemal predominant	III-IV	Reg. I +XRT
Focal anaplastic Wilms tumor	IV	Revised H-1+XRT
Diffuse anaplastic Wilms tumor	II-IV	Revised UH-1+XRT

CR= Complete Response

XRT= Radiation therapy

VAD= Vincristine, dactinomycin and doxorubicin

EE4A= Vincristine and dactinomycin

I= Vincristine, dactinomycin, doxorubicin, cyclophosphamide and etoposide

UH-1 = Vincristine, dactinomycin doxorubicin cyclophosphamide carboplatin and etoposide