Table III.
Particle size characterization & transcorneal Δ8-Tetrahydrocannabinol flux from various formulations. Transcorneal flux determined using side-by-side diffusion apparatus at 34°C. Data represents mean±SD (n=3)
| Code | Formulation | Particle Size (nm) | Polydispersity Index | Flux Across Isolated Corneas (μg/min/cm2) |
|---|---|---|---|---|
| F-0 | SLNs with Compritol - 0.1% Load) | 495 | 0.39 | 0.014 ± 0.005 |
| F-2 | SLNs with Compritol −0.75% Load | 390 | 0.32 | 0.17 ± 0.04 |
| F-3 | SLNs with Compritol & RMßCD in Aqueous Phase - 0.75% Load | 395 | 0.34 | 0.21 ± 0.009 |
| F-4 | SLNs with Compritol & RMßCD Complexed with THC- 0.75% Load | 410 | 0.34 | 0.23 ± 0.01 |
| F-5 | Film | – | – | 0.21 ± 0.05 |