Table 1.

Potential treatments highlighted in this article that have been shown to reduce JCPyV infection and/or PML progression.

Potential PML Treatment	FDA Licensed	Mechanism of Action	Tested in Clinical Setting
Mefloquine	Yes	Viral Replication Inhibitor	Yes
Mirtazapine	Yes	Serotonin Receptor Antagonist – Possible Receptor Competition	Yes
Retro-2	No	Intracellular Transport Inhibitor	No
VP1 Subunit Vaccine	No	Active Immunization	Yes
VLP Vaccine	No	Active Immunization	Yes
Anti-VP1 mAb	No	Passive Immunization	Yes
LSTc competitive inhibitors	No	Receptor Competition	No