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Tissue-Specific Distribution of IR Isoforms and Their Putative Activation by Either Insulin or IGF-2 During Fasting and Fed Conditions
| Tissue/Organ | IR Isoform |
Fasting |
Fed |
||
|---|---|---|---|---|---|
| Insulin | IGF-2 | Insulin | IGF-2 | ||
| Liver | IR-B | + | − | +++ | − |
| Muscle/fat | IR-B | + | − | +++ | − |
| IR-A | ± | +++ | +++ | + | |
| Brain | IR-A | ± | +++ | +++ | + |
Symbols indicate the putative relevance of each ligand on the specific IR isoform.
