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. Author manuscript; available in PMC: 2017 Oct 5.
Published in final edited form as: Nat Rev Endocrinol. 2017 Jan 20;13(4):195–207. doi: 10.1038/nrendo.2016.205

Figure 2.

Figure 2

Pituitary tissues express ectopic CTLA4 protein. Binding to CTLA4 autoantibodies or Ipilimumab IgG1 is thought to lead to activation of classical complement pathway.