Skip to main content
. Author manuscript; available in PMC: 2018 Oct 3.
Published in final edited form as: Cell Metab. 2017 Aug 24;26(4):598–609. doi: 10.1016/j.cmet.2017.07.020

Figure 1. Lymphatic vascular defects contribute to adult-onset obesity.

Figure 1

In Prox1+/− mice, compromised lymphatic vascular integrity causes subtle leakage of lymph. FFA-containing lymph accumulates in the nearby tissues, particularly in the visceral area where it induces de novo differentiation of fat cell precursors, fat cell hypertrophy and eventually adipocyte proliferation. With age, Prox1+/− mice became progressively obese.