Table 1.

Pharmacokinetic parameters of oxycodone after a single oral dose of test and reference tablets (10 mg) under fasting conditions in healthy male Japanese subjects (study 1)

Variables	Test (N = 24)	Reference (N = 24)
C max (ng/ml)	11.6 (26.2)	10.5 (22.8)
AUCt (ng·h/ml)	123 (22.7)	124 (25.1)
AUCinf (ng·h/ml)	124 (22.9)	126 (24.9)
t max (h)	3.00 (1.00; 6.00)	2.25 (1.00; 5.00)
t ½ (h)	4.32 ± 0.486	5.89 ± 0.783

Values are geometric mean (%CV), except for t _max, which is presented as median (minimum; maximum), and t _½, which is presented as arithmetic mean ± standard deviation

AUC _inf AUC up to infinity, AUC _t area under the plasma concentration–time curve to the last sampling time, C _max maximum plasma concentration, %CV coefficient of variation, t _max time to reach maximum concentration, t _½ terminal elimination half-life