Table 1.

Comparison of physical characteristics of select NSAIDs to Lipinski’s Rule of 5 [42, 44, 103–105]

	Lipinski’s Rule of 5	Ibuprofen	Ketoprofen	Diclofenac	Celecoxib
Molecular weight, (Da)	< 500	206	254	296	381
H-bond donors	< 5	1	1	2	1
H-bond acceptors	< 10	2	3	3	7
Log P	< 5	3.97	3.1	4.4	3.4