Table 1.

Description of the patients involved in the outbreak.

Case number	Age bracket	Speciality at admission	Specimen of first isolate	Subsequent clinical isolate (n days between screen and clinical isolate)a	Any antibiotic therapy prior to identification of NDM infectionb	CPE antibiotic therapy used post NDM identification	Initial colistin MIC (mg/L)c	Highest colistin MIC (mg/L)d	Colistin resistant at any stage
KP_NDM1	81–90	Renal	Urine	—	Amikacin	No antibiotics	<0.05	8	Yes
KP_NDM2	51–60	Vascular	Screening	Liver abscess (5)	Amikacin Metronidazole Piperacillin/Tazobactam Vancomycin	Colistimethate sodium Tigecycline	<0.05	16	Yes
KP_NDM3	81–90	Orthopaedic	Urine	—	None identified	No antibiotics	<0.05
KP_NDM4	61–70	Renal	Abdominal fluid	—	Ciprofloxacin Meropenem Metronidazole Piperacillin/Tazobactam Vancomycin	No antibiotics	<0.05	1
KP_NDM5	51–60	Vascular	Urine	—	None identified	No antibiotics	<0.05
KP_NDM6	61–70	Cardiac	Wound (Leg)	—	Meropenem	Colistimethate sodium Tigecycline	Not done	<0.05
KP_NDM7	71–80	Renal	Screening	Leg swab and tissue, urine (22)	None identified	Colistimethate sodium Tigecycline	4	8	Yes
KP_NDM8	71–80	Vascular	Screening	None	None identified	No antibiotics	32		Yes
KP_NDM9	71–80	Renal	Screening	Urine, central veneous catheter tip (4)	Meropenem	Colistimethate sodium Tigecycline,	8		Yes
KP_NDM10	71–80	Renal	Screening	None	Nystatina	No antibiotics	<0.05
KP_NDM11	81–90	Cardiac	Screening	None	None identified	Colistimethate sodium Tigecycline	32		Yes
KP_NDM12	61–70	Renal	Screening and urine	—	Cotrimoxazoled	Colistimethate sodium Tigecycline	8	8	Yes
KP_NDM13	61–70	Cardiac	Screening	None	None identified	No antibiotics	8		Yes
KP_NDM14	81–90	Cardiac	Screening	None	Cefalexin	No antibiotics	Not available
KP_NDM15	61–70	Cardiac	Screening	None	Amikacin Clarithromycin Co–amoxiclav Piperacillin/Tazobactam Vancomycin	No antibiotics	<0.05
KP_NDM16	81–90	Renal	Screening	Groin wound swab (16)	Meropenem	Tigecycline	8		Yes
KP_NDM17	71–80	Renal	Screening	Urine and mouth ulcers (235)	Co–amoxiclav Piperacillin/Tazobactam Vancomycin	Tigecycline	16		Yes
KP_NDM18	51–60	Renal	Screening	None	Ciprofloxacin Cotrimoxazoled Metronidazole Piperacillin/Tazobactam, Vancomycin,	No antibiotics	32		Yes
KP_NDM19	81–90	Renal	Screening	Urine (6)	Meropenem	Tigecycline	<0.5
KP_NDM20	71–80	Renal	Screening	Wound swab (11)	None identified	No antibiotics	<0.5	>32	Yes
KP_NDM21	51–60	Renal	Screening	Urine (15)	None identified	No antibiotics	1
KP_NDM22	61–70	Renal	Screening	Urine (254)	None identified	No antibiotics	Not done
KP_NDM23	61–70	Vascular	Wound (surgical)	—	Ciprofloxacin, Vancomycin	No antibiotics	32	16	Yes
KP_NDM24	61–70	Cardiac	Screening	None	Co-amoxiclav Ciprofloxacin Vancomycin	No antibiotics	4		Yes
KP_NDM25	71–80	Intensive Care	Screening	Wound swabs (groin and thigh) (28)	Metronidazole Piperacillin/Tazobactam Vancomycin	Colistimethate sodium Tigecycline	4		Yes
KP_NDM26	61–70	Renal	Screening	None	Piperacillin/Tazobactam, Vancomycin	No antibiotics	16		Yes
KP_NDM27	21–30	Intensive Care	Screening	None	Co-trimoxazoled Valganciclovird	No antibiotics	16		Yes
KP_NDM28	31–40	Intensive Care	Screening	None	Amikacin Linezolid Liposomal amphotericin,	No antibiotics	4		Yes
KP_NDM29	71–80	Vascular	Soft tissue and bone (foot)	—	Amikacin Piperacillin/ Tazobactam, Vancomycin,	No antibiotics	8	2	Yes
KP_NDM30	61–70	Cardiac	Screening	None	Ceftriaxone	Colistimethate sodium Tigecycline	1
KP_NDM31	81–90	Emergency Medicine	Screening	Urine (3)	Ceftriaxone Flucloxacillin Gentamycin, Metronidazole Rifampicin	No antibiotics	8		Yes
KP_NDM32	51–60	Maternity	Screening	Urine (18)	Amikacin, Caspofungin Co-trimoxazoledd Ciprofloxacin Metronidazole, Vancomycin	No antibiotics	8	8	Yes
KP_NDM33	51–60	Intensive Care	Screening	Central veneous catheter tip, abdominal wound (5)	Co-trimoxazoled Meropenem, Nystatind	No antibiotics	8		Yes
KP_NDM34	21–30	Renal	Screening	None	Piperacillin/Tazobactam	No antibiotics	16		Yes
KP_NDM35	51–60	Renal	Soft tissue and bone (foot)	—	Ciprofloxacin, Clindamycin Vancomycin,	Colistimethate sodium, Tigecycline	<0.5
KP_NDM36	61–70	Vascular	Screening	None	Anidulanfungin Meropene Rifaximin Vancomycin	No antibiotics	<0.5
KP_NDM37	91–100	Vascular	Screening	None	Ceftriaxone	No antibiotics	<0.5
KP_NDM38	0–10	Vascular	Screening	None	Benzylpenicillin Colistimethate sodium, Gentamicin	No antibiotics	8		Yes
KP_NDM39	51–60	Vascular	Screening	None	None identified	Colistimethate sodium, Tigecycline	<0.5
KP_NDM40	61–70	Vascular	Screening	None	Isoniazidd	No antibiotics	8		Yes

^aColumn denotes patients who were initially identified by screening, but had a subsequent clinical isolate, the site of the first clinical isolate, and the time between the screen and the first clinical isolate.

^bIdentified through case note review/electronic pharmacy records for period 2014/15.

^cBold font denotes colistin resistance (>2 mg/L).

^dProphylaxis post-transplant as part of approved protocols.