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. 2017 Aug 1;469(11):1485–1493. doi: 10.1007/s00424-017-2038-3

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Effect of charge neutralization in IIS4 and IIIS4 on steady-state inactivation and activation. Steady-state inactivation (left panels) and activation (right panels) curves of WT, IIS4, IIIS4, and IVS4 mutants. Representative barium currents through WT and mutant channels during a 3000-ms depolarization from −80 mV to the peak potential (PP) of the I–V curves are shown in corresponding insets. WT (PP 10 mV); IIS4(R2Q/R3Q/R4Q/K5Q/R6Q) (PP 10 mV); IIIS4(K1Q/R2Q/R3Q/R4Q) (PP 10 mV); IVS4(R2Q) (PP 20 mV)