Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 1;469(11):1485–1493. doi: 10.1007/s00424-017-2038-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Fig. 4 — Charge neutralizations in Cav1.2 segments IS4–IVS4 differently affect the position and slope of the inactivation curve. a–c Shifts of the midpoint voltages (V _0.5,inact closed bars,V _0.5,act open bars) of a IS4 , b IIS4 and IIIS4, and c IVS4-mutants compared to WT. d Slope factors of inactivation curves were significantly (*p < 0.05) decreased by charge neutralization in IS4 and IVS4. Strongest changes were observed for mutants IS4((K0Q/R1Q/R2Q) with k _inact. = 8.2 ± 0.6 mV; IS4(K1Q/R2Q/R3Q/R4Q) with k _inact. = 6.2 ± 0.7 mV; IVS4(R2Q) with k _inact. = 10.2 ± 1.2 mV; IVS4(R4Q) with k _inact. = 9.7 ± 0.7 mV and IVS4(K5Q) with k _inact. = 8.1 ± 0.7 mV. Neutralization of either single or combined charge neutralizations in IIS4 and IIIS4 had no significant effect on the slope factors of steady-state inactivation curves (Table 1)