Table 2.
Motoneuron properties separated by group
| Lean | Obese | Diabetic | |
|---|---|---|---|
| Input conductance, 10−6 S | 0.48 (0.2); n = 66 | 0.53 (0.42); n = 43 | 0.48 (0.28); n = 54 |
| High IC, 10−6 S | 0.56 (0.16); n = 34 | 0.78 (0.29); n = 20 | 0.67 (0.18); n = 27 |
| Low IC, 10−6 S | 0.33 (0.11); n = 32 | 0.35 (0.16); n = 23 | 0.39 (0.19); n = 27 |
| Rheobase, mV | 7.2 (7.3); n = 58 | 7.8 (8.1); n = 40 | 7.5 (6.6); n = 49 |
| Rheobase–high IC, mV | 10.25(5.8); n = 29 | 10.7 (5.8); n = 19 | 8.5 (5.3); n = 25 |
| Rheobase–low IC, mV | 4.75 (3.0); n = 29 | 4.5 (6.8); n = 21 | 5.6 (7.8); n = 24 |
| AHPAMP–high IC, mV | 1.22 (0.55); n = 34 | 1.25 (0.60); n = 20 | 1.19 (0.70); n = 26 |
| AHP1/2–high IC, ms | 12.20 (2.8); n = 34 | 11.3 (2.8); n = 20 | 12.0 (2.4); n = 26 |
| AHPAMP–low IC, mV | 1.8 (2.8); n = 32 | 1.5 (1.5); n = 22 | 1.2 (0.9); n = 25 |
| AHP1/2–low IC, ms | 15.35 (6.7); n = 32 | 12.5 (8.0); n = 22 | 12.3 (3.8); n = 25 |
| Adaptation index, a.u. | 0.21 (0.25); n = 25 | 0.15 (0.27); n = 21 | 0.19 (0.14); n = 27 |
| Fast F/I | One linear range = 9 | One linear range = 9 | One linear range = 12 |
| Two linear ranges = 15 | Two linear ranges = 15 | Two linear ranges = 16 | |
| F/I slope, Hz⋅nA | 29.75 (12.43) | 30.12 (24.33) | 34.77 (16.35) |
| IPK, nA | 12.87 (10.70) | 11.10 (11.00) | 14.96 (11.01) |
| IMN, nA | 7.03 (7.04) | 9.20 (9.59) | 8.26 (11.12) |
| RatePK, Hz | 246.31 (194.84) | 187.34 (200.15) | 206.19 (187.34) |
| RateMN, Hz | 38.74 (56.27) | 59.99 (84.22) | 56.98 (60.88) |
| Slow F/I | n = 43 | n = 30 | n = 40 |
| F/I slope, Hz⋅nA | 9.71 (8.15) | 11.05 (4.89) | 10.38 (6.2) |
| IPK, nA | 10.08 (9.76) | 10.5 (8.93) | 14.08 (9.14) |
| IMN, nA | 7.17 (9.72) | 7.75 (8.77) | 11.28 (9.2) |
| RatePK, Hz | 48.40 (19.34) | 50.53 (29.64) | 56.61 (22.30) |
| RateMN, Hz | 10.87 (13.69) | 9.54 (10.9) | 9.23 (12.71) |
Data are the median value and interquartile range (IQR) in parentheses; n = no. of motoneurons. Bold type indicates a significant difference from the lean group (P < 0.05). Italic type indicates a tendency to differ from the lean group (P < 0.07). IPK, mean peak depolarizing current; IMN, mean minimum depolarizing current; RatePK, mean peak motoneuron discharge rate, RateMN, mean minimum motoneuron discharge rate. For the fast F/I relationship, “one linear range” indicates that a single linear relationship occurred between motoneuron discharge rate and depolarizing current amplitude, whereas “two linear ranges” indicates that a primary and secondary range of firing with different F/I slopes existed. A motoneuron displaying two linear ranges had a primary range with a lower slope than the secondary slope. The F/I slope for the primary range was used for the mean comparisons between the groups.