eTable 1. Demographic and biometric patient data.

	All patients	Lidocaine	Vapocoolant spray	Control
Number of patients n	450	150	150	150
Sex (m : f)
All cannula sizes	194 : 256	65 : 85	63 : 87	66 : 84
17 G n	99 : 126	30 : 45	34 : 41	35 : 40
20 G n	95 : 130	35 : 40	29 : 46	31 : 44
Age
All cannula sizes years	49.6 ± 16.8	49.5 ± 15.9	49.0 ± 18.0	51.0 ± 16.3
17 G years	50.1 ± 16.4	47.8 ± 17.6	48.7 ± 15.4	54.1 ± 15.5
20 G years	49.2 ± 17.3	51.1 ± 14.0	49.2 ± 20.5	47.9 ± 16.7

Data are shown as frequencies or means ± standard deviations.