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. Author manuscript; available in PMC: 2017 Oct 6.
Published in final edited form as: Gene. 2015 May 14;567(2):132–137. doi: 10.1016/j.gene.2015.04.087

Figure 2. Canonical JAK/STAT signalling pathway of type I-IFNs.

Figure 2

Type I-IFN/IFNAR2/IFNAR1 ternary complex induces transphosphorylation of receptor associated JAK kinases which in turn phosphorylate specific tyrosine residues on IFNAR1 and IFNAR2. These phosphorylated tyrosine residues are docking sites for signal transducers and activators of transcription (STAT) which are then recruited to the receptor complex and phosporylated (pSTAT) on specific tyrosine residue. pSTAT2 and pSTAT1 heterodimerize to form together with IRF9 the ISGF3 complex which translocates into the nucleus and binds to IFN stimulated responsive elements (ISRE) in the regulatory region of IFN-stimulated genes (ISG)