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. Author manuscript; available in PMC: 2017 Oct 6.
Published in final edited form as: Biochemistry. 2017 Mar 27;56(13):1815–1823. doi: 10.1021/acs.biochem.7b00007

Figure 3.

Figure 3

Model of eukaryotic heme transport and trafficking. The final step of heme synthesis occurs in the mitochondrial matrix, and heme must be transported out of the mitochondria and incorporated into a multitude of hemoproteins found in different compartments. This process is likely mediated by heme chaperones and transporters. Proteins previously implicated in heme transport, trafficking, or buffering are identified, and trafficking pathways that are currently unknown are marked with question marks.