Figure 2.

Dendritic cells treated with 1,25‐dihydroxyvitamin D₃ (VD ₃‐DCs) alleviate clinical symptoms and reduce spinal cord damage in experimental autoimmune encephalomyelitis (EAE) (models were induced in female C57BL/6 mice). (a) The clinical score of EAE after adoptive transfer of VD ₃‐DCs and DCs. VD ₃‐DCs and DCs reduce the severity of EAE. (b) Kaplan–Meier survival analysis comparing the onset time of the VD ₃‐DCs group, DCs group and controls. VD ₃‐DCs postpone the onset of EAE significantly. (c) Inflammatory cell infiltration and structural damage to the spinal cord are more severe in controls than in the VD ₃‐DCs group and DCs group. Experiments were replicated three times (n = 10). [Colour figure can be viewed at wileyonlinelibrary.com]