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. 2017 Jul 31;152(3):507–516. doi: 10.1111/imm.12789

Figure 3.

Figure 3

Naive population from CD25− CD4+ T cells was mainly affected by IC87114. CD25− CD4+ T cells were sorted into CD62L+ [labelled with carboxyfluorescein succinimidyl ester (CFSE)] and CD62L− (labelled with violet tracker) fractions. Both populations were then cultured together at a ratio representing the initial CD25− CD4+ T‐cell population, and differentiated into interleukin‐27‐induced type 1 regulatory T (IL‐27–Tr1) cells, with or without addition of IC87114. The table represents IL‐10 expression analysed among divided cells in both fractions, and (%) represents inhibitory rate by IC87114. Results are representative of three independent experiments.