Fig. 6.

Dynamic simulations of Maff and Egr3-mediated alterations of cell cycle. a-c Steady states of Cyc D* (a), Cyc E* (b) and E2F (c) with respect to k _s _maff under medium Egr3 expression level (low < k _s_egr3 < high) are shown herein. In this circumstance, higher Maff expression is able to uplift the levels of Cyc D*, Cyc E* and E2F, resulting in bistability in their steady states (red lines). Dynamics of the three molecules under low Egr3 expression level (with respect to k _s _maff) are equivalent to Fig. 2a-c, in which high expression of Egr3 is not presumed (k _s_egr3 = low). d-f Steady states of Cyc D* (d), Cyc E* (e) and E2F (f) with respect to k _s _maff under high Egr3 expression level (k _s_egr3 = high). In this circumstance, increase in Maff expression (k _s _maff) is unable to effectively uplift the steady states of Cyc D*, Cyc E* and E2F any more. g-i Steady states of Cyc D* (g), Cyc E* (h) and E2F (i) with respect to k _s _egr3 when Maff expression level is high (k _s _maff = high). The situation is similar to those of Fig. 3a - c (k _s _maff = low), in which high Egr3 expression potently suppresses the steady-state levels of all three molecules. The results indicate that no matter Maff expression is high or low, cell cycle is suppressed when Egr3 is highly expressed