Table 6.

List of model parameters and ranges of possible values

Parameter	Range of possible values
Minimum number of ANP divisions, m i n ANP	1,2,3
Maximum number of ANP divisions, m a x ANP	2,...,8
Renewal probability of ANP, p ANP	{0,0.1,...,0.99,1}
Distribution coefficients of ANP G 1-phase duration, $T_{G_1-\mathit{\text{ANP}}}$	6,...,20hr; {2,...,16}; {2,...,5}h r
Distribution coefficients of ANP S-phase duration, T S−ANP	{5,...,12}h r; {5,...,40}; {1,...,4}h r
Distribution coefficients of ANP G 2 M-phase duration, $T_{G_{2}M-\mathit{\text{ANP}}}$	{1,...,4}h r; {5,...,20}; {0,...,0.75}h r
Distribution coefficients of ANP-NB stage duration1, T ANP−NB	{4,...,64}h r; {2,...,16}; {0,...,3}h r
Distribution coefficients of ANP-Apop stage duration2, T ANP−Apop	{4,...,64}h r; {2,...,16}; {0,...,3}h r
Distribution coefficients of NB duration, T NB	{120,...,430}h r; {2,...,16}; {10,...,80}h r
Distribution coefficients of Apoptotic cell duration, T Apop	{0.4,...,3}h r; {2,...,16}; {0,...,0.3}h r
Cell death rate of ANP G 1-phase, $d_{G_1}$	{0,0.1,...,0.98,0.99}
Cell death rate of ANP S-phase, d S	{0,0.1,...,0.98,0.99}
Cell death rate of ANP G 2 M-phase, $d_{G_{2}M}$	{0,0.1,...,0.98,0.99}
Cell death rate of non-proliferating ANP, d ANP	{0,0.1,...,0.98,0.99}
Cell death rate of NB, d NB	{0,0.1,...,0.98,0.99}
Minimum number of NSC divisions, m i n QNP	{1,2,3}
Maximum number of NSC divisions, m a x QNP	{2,...,6}
Renewal probability of NSC, p QNP	{0,0.1,...,0.99,1}
Distribution coefficients of NSC G 1-phase duration, $T_{G_1-\mathit{\text{QNP}}}$	{8,...,36}h r; {2,...,16}; {2,...,5}h r
Distribution coefficients of NSC S-phase duration, T S−QNP	{5,...,12}h r; {5,...,40}; {1,...,4}h r
Distribution coefficients of NSC G 2 M-phase duration, $T_{G_{2}M-\mathit{\text{QNP}}}$	{1,...,4}h r; {5,...,20}; {0,...,0.75}h r

¹If a non-proliferative ANP is determined to differentiate to a NB, it enters ANP-NB stage,

²otherwise it enters ANP-Apop stage before undergoing apoptosis. Since the cell duration (transit time) is modeled by a shifted gamma distribution the duration distribution parameter for any cell type i, T _i, consists of 3 coefficients that are expected duration, shape parameter of the gamma distribution and the minimum duration (shift value). A range of values for each of these three coefficients has been provided