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Mechanism of H2S release from esterase-cleaved prodrugs. Prodrugs of this category release H2S upon cleavage of an ester group, followed by lactonization. H2S release rates can be changed by 1) modifying the ester group (acyl moiety) and thus altering susceptibility to esterase and 2) altering structural features that are crucial for the lactonization rate. BW-HP-101 is shown as an example.
