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Opsonophagocytic assay with sera from an HMW1/HMW2-immunized (indicated as HMW) and an OMV-immunized (indicated as OMV) chinchilla, each assayed against a NTHi strain recovered from the middle ear fluid of a Freund's immunized animal (indicated as Control) or an HMW1/HMW2-downregulated strain recovered from the middle ear fluid of an HMW1/HMW2-immunized and infected animal (indicated as HMW Down).
