TABLE 1.
Summary of vaccine-induced immune responses
| Parameter | Response to indicated vaccine regimen |
|||
|---|---|---|---|---|
| Accelerated interval |
Extended interval coadmininistration | |||
| Env protein | Prime/boost | Coadministration | ||
| Plasma IgG | ||||
| Magnitude | ++ | ++ | ++ | ++ |
| Breadth | +++ | + | ++ | ++ |
| Epitope recognition | ||||
| Magnitude | ++ | + | ++ | ++ |
| Breadth | ++ | + | ++ | ++ |
| Bone marrow plasmablasts | + | + | ++ | ++ |
| Mucosal IgA | +/− | +/− | +/− | + |
| Avidity | +++ | + | ++ | ++++ |
| ADCC | ++ | + | ++ | ++ |
| Tier 1 neutralizing antibody | +++ | + | ++ | ++ |
| gp120-specific B cells | ||||
| Spleen | ++ | + | ++ | ++ |
| LNs | ++ | + | ++ | ++ |
| Colon | +/− | +/− | +/− | + |
| TFH cells | ||||
| Frequency | ++ | ++ | ++ | ++ |
| Function | ++ | + | ++ | ++ |
| SIV Gag-specific T cells | ||||
| Frequency | ++ | ++ | ++ | ++ |
| Function | ++ | ++ | ++ | ++ |