Table 2.

Multivariate analysis of the interaction between IAH and clinical symptoms

Symptom	Variable	HR†	95% CI	p Value
Sepsis	IAH	3.64	2.50 to 5.29	<0.001*
	Sepsis	1.30	0.94 to 1.81	0.112
	Interaction	0.52	0.25 to 1.07	0.076
Neurological	IAH	3.27	2.25 to 4.76	<0.001*
	Neurological	0.99	0.67 to 1.46	0.95
	Interaction	2.31	1.09 to 4.90	0.029*
CVD	IAH	3.30	2.26 to 4.82	<0.001*
	CVD	0.78	0.47 to 1.30	0.34
	Interaction	3.03	1.29 to 7.15	0.011*
Respiratory	IAH	3.69	2.49 to 5.47	<0.001*
	Respiratory failure	1.38	0.96 to 1.98	0.079
	Interaction	0.73	0.37 to 1.48	0.39
AKI	IAH	3.64	2.51 to 5.30	<0.001*
	AKI	1.01	0.71 to 1.42	0.97
	Interaction	0.56	0.27 to 1.17	0.12

*p<0.05.

^†Adjusted for age, gender, APACHE-II score, renal replacement therapy and mechanical ventilation.

AKI, acute kidney injury; CVD, cerebrovascular disease; IAH, intensive care unit-acquired hypernatraemia.