Table 2.

Association (β 95% CI) between antidepressant use and annual weight gain

	Non-user	1–2 prescriptions/year	>2 prescriptions/year	p Value
Any antidepressant
n	1934	188	212
Baseline weight (kg), mean (SD)	80.0 (17.0)	77.1 (16.5)	81.3 (19.1)
Follow-up weight (kg), mean (SD)	80.6 (17.3)	78.0 (17.2)	82.5 (19.6)
Annual weight change (kg), mean (SD)	0.12 (1.32)	0.18 (1.54)	0.28 (1.99)
Model 1*	Ref	0.15(−0.06 to 0.36)	0.22 (0.02 to 0.42)	0.022
Model 2†	Ref	0.18(−0.04 to 0.40)	0.25 (0.04 to 0.46)	0.009
Model 3‡	Ref	0.11(−0.11 to 0.34)	0.22 (0.00 to 0.44)	0.044
SSRIs
n	2109	114	111
Baseline weight (kg), mean (SD)	79.8 (17.0)	79.7 (18.2)	82.2 (19.1)
Follow-up weight (kg), mean (SD)	80.3 (17.3)	81.2 (18.0)	84.9 (21.2)
Annual weight change (kg), mean (SD)	0.11 (1.33)	0.38 (2.11)	0.61 (1.89)
Model 1*	Ref	0.30 (0.04 to 0.57)	0.53 (0.27 to 0.80)	<0.001
Model 2†	Ref	0.30 (0.03 to 0.58)	0.58 (0.30 to 0.85)	<0.001
Model 3‡	Ref	0.30 (0.01 to 0.58)	0.48 (0.20 to 0.76)	<0.001
TCAs
n	2212	79	43
Baseline weight (kg), mean (SD)	80.1 (17.2)	76.3 (17.8)	77.3 (15.9)
Follow-up weight (kg), mean (SD)	80.8 (17.5)	75.5 (17.3)	77.3 (16.4)
Annual weight change (kg), mean (SD)	0.16 (1.40)	−0.13 (1.61)	−0.01 (1.32)
Model 1*	Ref	−0.12(−0.44 to 0.19)	0.06(−0.36 to 0.49)	0.717
Model 2†	Ref	−0.11(−0.44 to 0.22)	0.05(−0.39 to 0.50)	0.704
Model 3‡	Ref	0.02(−0.31 to 0.36)	0.03(−0.46 to 0.52)	0.908
Other antidepressants
n	2210	57	67
Baseline weight (kg), mean (SD)	79.8 (17.0)	80.0 (18.7)	82.9 (20.5)
Follow-up weight (kg), mean (SD)	80.4 (17.4)	81.3 (17.6)	83.4 (21.2)
Annual weight change (kg), mean (SD)	0.14 (1.37)	0.35 (1.88)	0.12 (2.08)
Model 1*	Ref	0.23(−0.13 to 0.60)	−0.04(−0.38 to 0.29)	0.844
Model 2†	Ref	0.32(−0.05 to 0.70)	−0.01(−0.36 to 0.35)	0.505
Model 3‡	Ref	0.42 (0.03 to 0.80)	−0.19(−0.56 to 0.19)	0.926

*Model 1 adjusted for age and gender.

†Model 2 further adjusted for baseline income, smoking, physical activity, follow-up duration.

‡Model 3 further adjusted for depression status at baseline and follow-up, dietary patterns (continuous).

SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant.