Table 1.
Characteristic, Charlson Comorbidity Index and clinical conditions among men with and without type 2 diabetes hospitalised with vascular dementia
| 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | Total | p Value | |
| No diabetes | ||||||||||||
| N | 4185 | 4511 | 4697 | 4889 | 5152 | 5346 | 5705 | 5892 | 5877 | 6083 | 52 337 | <0.001 |
| Incidence per 100 000 inhabitants | 255.04 | 256.93 | 251.11 | 261.37 | 280.32 | 296.14 | 316.02 | 325.64 | 324.81 | 335.44 | 290.47 | |
| Age, mean (SD) | 81.28 (6.01) | 81.32 (5.82) | 81.64 (5.92) | 82 (6.06) | 81.9 (5.95) | 82.61 (5.95) | 82.78 (5.83) | 83.01 (5.71) | 83.15 (5.88) | 83.41 (5.76) | 82.4 (5.93) | <0.001 |
| 70–74 years old, n (%) | 626 (14.96) | 610 (13.52) | 572 (12.18) | 597 (12.21) | 630 (12.23) | 509 (9.52) | 513 (8.99) | 426 (7.23) | 491 (8.35) | 461 (7.58) | 5435 (10.38) | 0.000 |
| 75–79 years old, n (%) | 1053 (25.16) | 1154 (25.58) | 1173 (24.97) | 1132 (23.15) | 1215 (23.58) | 1167 (21.83) | 1162 (20.37) | 1223 (20.76) | 1071 (18.22) | 1075 (17.67) | 11 425 (21.83) | |
| 80–84 years old, n (%) | 1247 (29.8) | 1413 (31.32) | 1493 (31.79) | 1490 (30.48) | 1541 (29.91) | 1556 (29.11) | 1760 (30.85) | 1839 (31.21) | 1808 (30.76) | 1878 (30.87) | 16 025 (30.62) | |
| ≥85 years old, n(%) | 1259 (30.08) | 1334 (29.57) | 1459 (31.06) | 1670 (34.16) | 1766 (34.28) | 2114 (39.54) | 2270 (39.79) | 2404 (40.8) | 2507 (42.66) | 2669 (43.88) | 19 452 (37.17) | |
| Charlson Comorbidity Index 1, n (%) | 934 (22.32) | 962 (21.33) | 1019 (21.69) | 1015 (20.76) | 1119 (21.72) | 1124 (21.03) | 1119 (19.61) | 1113 (18.89) | 1091 (18.56) | 1126 (18.51) | 10 622 (20.3) | 0.000 |
| Charlson Comorbidity Index 2, n (%) | 1748 (41.77) | 1968 (43.63) | 1927 (41.03) | 2048 (41.89) | 2072 (40.22) | 2195 (41.06) | 2281 (39.98) | 2330 (39.55) | 2219 (37.76) | 2359 (38.78) | 21 147 (40.41) | |
| Charlson Comorbidity Index ≥3, n (%) | 1503 (35.91) | 1581 (35.05) | 1751 (37.28) | 1826 (37.35) | 1961 (38.06) | 2027 (37.92) | 2305 (40.4) | 2449 (41.56) | 2567 (43.68) | 2598 (42.71) | 20 568 (39.3) | |
| Previous stroke | 1963 (46.91) | 2114 (46.86) | 2320 (49.39) | 2305 (47.15) | 2528 (49.07) | 2649 (49.55) | 2949 (51.69) | 2976 (50.51) | 3059 (52.05) | 3148 (51.75) | 26 011 (49.70) | <0.001 |
| Atrial fibrillation, n (%) | 830 (19.83) | 907 (20.11) | 1030 (21.93) | 1095 (22.4) | 1155 (22.42) | 1270 (23.76) | 1397 (24.49) | 1452 (24.64) | 1488 (25.32) | 1493 (24.54) | 12 117 (23.15) | <0.001 |
| Hypertension, n (%) | 1398 (33.41) | 1537 (34.07) | 1707 (36.34) | 1745 (35.69) | 1883 (36.55) | 2004 (37.49) | 2196 (38.49) | 2288 (38.83) | 2349 (39.97) | 2420 (39.78) | 19 527 (37.31) | <0.001 |
| Malnutrition, n (%) | 104 (2.49) | 177 (3.92) | 185 (3.94) | 231 (4.72) | 243 (4.72) | 274 (5.13) | 251 (4.4) | 308 (5.23) | 280 (4.76) | 339 (5.57) | 2392 (4.57) | <0.001 |
| Pneumonia, n (%) | 1028 (24.56) | 1180 (26.16) | 1136 (24.19) | 1260 (25.77) | 1303 (25.29) | 1448 (27.09) | 1526 (26.75) | 1594 (27.05) | 1603 (27.28) | 1638 (26.93) | 13 716 (26.21) | <0.001 |
| Urinary tract infection, n (%) | 682 (16.3) | 743 (16.47) | 790 (16.82) | 808 (16.53) | 881 (17.1) | 963 (18.01) | 992 (17.39) | 1079 (18.31) | 1108 (18.85) | 1150 (18.91) | 9196 (17.57) | 0.001 |
| Agitation, n (%) | 16 (0.38) | 16 (0.35) | 16 (0.34) | 24 (0.49) | 22 (0.43) | 31 (0.58) | 36 (0.63) | 34 (0.58) | 32 (0.54) | 39 (0.64) | 266 (0.51) | 0.225 |
| Diabetes | ||||||||||||
| N | 1703 | 2000 | 2297 | 2376 | 2578 | 2735 | 2887 | 3057 | 3313 | 3216 | 26 162 | <0.001 |
| Incidence | 450.73 | 501.91 | 548.05 | 566.9 | 578.82 | 579.89 | 612.11 | 591.26 | 640.77 | 571.82 | 568.77 | |
| Age, mean (SD) | 79.6 (5.59) | 79.74 (5.58) | 79.84 (5.57) | 80.2 (5.6) | 80.43 (5.6) | 80.51 (5.65) | 81.01 (5.46) | 81.37 (5.62) | 81.49 (5.65) | 81.71 (5.66) | 80.72 (5.65) | <0.001 |
| 70–74 years old, n (%) | 342 (20.08) | 393 (19.65) | 438 (19.07) | 400 (16.84) | 413 (16.02) | 426 (15.58) | 376 (13.02) | 388 (12.69) | 392 (11.83) | 352 (10.95) | 3920 (14.98) | 0.000 |
| 75–79 years old, n (%) | 540 (31.71) | 621 (31.05) | 683 (29.73) | 752 (31.65) | 767 (29.75) | 791 (28.92) | 759 (26.29) | 789 (25.81) | 855 (25.81) | 811 (25.22) | 7368 (28.16) | |
| 80–84 years old, n (%) | 487 (28.6) | 599 (29.95) | 728 (31.69) | 669 (28.16) | 786 (30.49) | 855 (31.26) | 959 (33.22) | 939 (30.72) | 1048 (31.63) | 1019 (31.69) | 8089 (30.92) | |
| ≥85 years old, n (%) | 334 (19.61) | 387 (19.35) | 448 (19.5) | 555 (23.36) | 612 (23.74) | 663 (24.24) | 793 (27.47) | 941 (30.78) | 1018 (30.73) | 1034 (32.15) | 6785 (25.93) | |
| Charlson Comorbidity Index 1, n (%) | 348 (20.43) | 398 (19.9) | 490 (21.33) | 508 (21.38) | 509 (19.74) | 494 (18.06) | 513 (17.77) | 558 (18.25) | 594 (17.93) | 559 (17.38) | 4971(19) | 0.000 |
| Charlson Comorbidity Index 2, n (%) | 710 (41.69) | 784 (39.2) | 925 (40.27) | 942 (39.65) | 1079 (41.85) | 1095 (40.04) | 1191 (41.25) | 1200 (39.25) | 1341 (40.48) | 1234 (38.37) | 10 501 (40.14) | |
| Charlson Comorbidity Index ≥3, n (%) | 645 (37.87) | 818 (40.9) | 882 (38.4) | 926 (38.97) | 990 (38.4) | 1146 (41.9) | 1183 (40.98) | 1299 (42.49) | 1378 (41.59) | 1423 (44.25) | 10 690 (40.86) | |
| Previous stroke | 791 (46.45) | 992 (49.6) | 1071 (46.63) | 1099 (46.25) | 1267 (49.15) | 1437 (52.54) | 1476 (51.13) | 1517 (49.62) | 1660 (50.11) | 1695 (52.71) | 13 005 (49.71) | <0.001 |
| Atrial fibrillation, n (%) | 319 (18.73) | 409 (20.45) | 443 (19.29) | 454 (19.11) | 521 (20.21) | 574 (20.99) | 591 (20.47) | 639 (20.9) | 700 (21.13) | 678 (21.08) | 5328 (20.37) | 0.331 |
| Hypertension, n (%) | 780 (45.8) | 945 (47.25) | 1087 (47.32) | 1201 (50.55) | 1303 (50.54) | 1410 (51.55) | 1456 (50.43) | 1517 (49.62) | 1653 (49.89) | 1647 (51.21) | 12 999 (49.69) | 0.001 |
| Malnutrition, n (%) | 41 (2.41) | 58 (2.9) | 85 (3.7) | 73 (3.07) | 81 (3.14) | 110 (4.02) | 127 (4.4) | 121 (3.96) | 127 (3.83) | 117 (3.64) | 940 (3.59) | 0.010 |
| Pneumonia, n (%) | 390 (22.9) | 431 (21.55) | 490 (21.33) | 536 (22.56) | 599 (23.24) | 651 (23.8) | 706 (24.45) | 768 (25.12) | 804 (24.27) | 763 (23.73) | 6138 (23.46) | 0.024 |
| Urinary tract infection, n (%) | 299 (17.56) | 335 (16.75) | 351 (15.28) | 392 (16.5) | 449 (17.42) | 500 (18.28) | 520 (18.01) | 578 (18.91) | 580 (17.51) | 573 (17.82) | 4577 (17.49) | 0.059 |
| Agitation, n (%) | 6 (0.35) | 6 (0.3) | 6 (0.26) | 4 (0.17) | 10 (0.39) | 14 (0.51) | 13 (0.45) | 13 (0.43) | 20 (0.6) | 19 (0.59) | 111 (0.42) | 0.254 |
Analysis of the Spanish National Hospital Discharge Database from 2004 to 2013.
Charlson Comorbidity Index, excluding dementia and diabetes.
p Value for comparison by year.
Poisson regression model to assess trends in incidence rates, analysis of variance and Pearson's χ2 for means and proportions, respectively.
N, number of discharges.