Table 2.
Characteristic, Charlson Comorbidity Index and clinical conditions among women with and without type 2 diabetes hospitalised with vascular dementia
| 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | Total | p-value | |
| No diabetes | ||||||||||||
| N | 4489 | 5089 | 5018 | 5313 | 6007 | 6066 | 6448 | 6881 | 7167 | 7124 | 59 602 | |
| Incidence per 100 000 inhabitants | 192.92 | 210.3 | 199.7 | 211.44 | 234.61 | 232.59 | 247.23 | 260.71 | 271.55 | 266.76 | 233.75 | <0.001 |
| Age, mean (SD) | 83.93 (6.01) | 84.19 (5.99) | 84.27 (6.07) | 84.59 (5.94) | 84.76 (5.95) | 85.16 (5.88) | 85.24 (5.87) | 85.54 (5.75) | 85.65 (5.69) | 85.88 (5.79) | 85.01 (5.91) | <0.001 |
| 70–74 years old, n (%) | 340 (7.57) | 310 (6.09) | 328 (6.54) | 293 (5.51) | 289 (4.81) | 266 (4.39) | 260 (4.03) | 220 (3.2) | 246 (3.43) | 214(3) | 2766 (4.64) | <0.001 |
| 75–79 years old, n (%) | 693 (15.44) | 813 (15.98) | 770 (15.34) | 761 (14.32) | 879 (14.63) | 782 (12.89) | 844 (13.09) | 854 (12.41) | 787 (10.98) | 794 (11.15) | 7977 (13.38) | |
| 80–84 years old, n (%) | 1337 (29.78) | 1486 (29.2) | 1465 (29.19) | 1544 (29.06) | 1669 (27.78) | 1609 (26.52) | 1657 (25.7) | 1718 (24.97) | 1861 (25.97) | 1758 (24.68) | 16 104 (27.02) | |
| ≥85 years old, n (%) | 2119 (47.2) | 2480 (48.73) | 2455 (48.92) | 2715 (51.1) | 3170 (52.77) | 3409 (56.2) | 3687 (57.18) | 4089 (59.42) | 4273 (59.62) | 4358 (61.17) | 32 755 (54.96) | |
| Charlson Comorbidity Index 1, n (%) | 1346 (29.98) | 1640 (32.23) | 1565 (31.19) | 1615 (30.4) | 1849 (30.78) | 1746 (28.78) | 1736 (26.92) | 1808 (26.28) | 1913 (26.69) | 1772 (24.87) | 16 990 (28.51) | <0.001 |
| Charlson Comorbidity Index 2, n (%) | 2065(46) | 2264 (44.49) | 2242 (44.68) | 2382 (44.83) | 2656 (44.22) | 2734 (45.07) | 2957 (45.86) | 3093 (44.95) | 3112 (43.42) | 3131 (43.95) | 26 636 (44.69) | |
| Charlson Comorbidity Index ≥3, n (%) | 1078 (24.01) | 1185 (23.29) | 1211 (24.13) | 1316 (24.77) | 1502(25) | 1586 (26.15) | 1755 (27.22) | 1980 (28.77) | 2142 (29.89) | 2221 (31.18) | 15 976 (26.8) | |
| Previous stroke | 2048 (45.62) | 2333 (45.84) | 2357 (46.97) | 2406 (45.29) | 2747 (45.73) | 2906 (47.91) | 3185 (49.4) | 3427 (49.8) | 3478 (48.53) | 3552 (49.86) | 28 439 (47.71) | <0.001 |
| Atrial fibrillation, n (%) | 1185 (26.4) | 1311 (25.76) | 1368 (27.26) | 1447 (27.24) | 1645 (27.38) | 1634 (26.94) | 1799 (27.9) | 2015 (29.28) | 2068 (28.85) | 2021 (28.37) | 16 493 (27.67) | <0.001 |
| Hypertension, n (%) | 1889 (42.08) | 2160 (42.44) | 2196 (43.76) | 2461 (46.32) | 2759 (45.93) | 2945 (48.55) | 2988 (46.34) | 3197 (46.46) | 3409 (47.57) | 3441 (48.3) | 27 445 (46.05) | <0.001 |
| Malnutrition, n (%) | 152 (3.39) | 205 (4.03) | 231 (4.6) | 231 (4.35) | 301 (5.01) | 317 (5.23) | 352 (5.46) | 381 (5.54) | 365 (5.09) | 406 (5.7) | 2941 (4.93) | <0.001 |
| Pneumonia, n (%) | 783 (17.44) | 988 (19.41) | 898 (17.9) | 916 (17.24) | 1162 (19.34) | 1180 (19.45) | 1252 (19.42) | 1299 (18.88) | 1442 (20.12) | 1350 (18.95) | 11 270 (18.91) | <0.001 |
| Urinary tract infection, n (%) | 871 (19.4) | 999 (19.63) | 1077 (21.46) | 1070 (20.14) | 1308 (21.77) | 1394 (22.98) | 1475 (22.88) | 1634 (23.75) | 1565 (21.84) | 1681 (23.6) | 13 074 (21.94) | <0.001 |
| Agitation, n (%) | 13 (0.29) | 18 (0.35) | 19 (0.38) | 15 (0.28) | 27 (0.45) | 20 (0.33) | 21 (0.33) | 41 (0.6) | 21 (0.29) | 31 (0.44) | 226 (0.38) | 0.103 |
| Diabetes | ||||||||||||
| N | 2326 | 2553 | 2852 | 2920 | 3192 | 3525 | 3546 | 3841 | 3852 | 3899 | 32 506 | |
| Incidence | 410.63 | 457.16 | 518.13 | 530.48 | 533.07 | 544.7 | 547.95 | 524.92 | 526.42 | 477.63 | 508.01 | <0.001 |
| Age, mean (SD) | 82.01 (5.83) | 82.21 (6.07) | 82.43 (6.06) | 82.75(6) | 83.12(6) | 83.16 (5.85) | 83.35 (5.75) | 83.72 (5.87) | 83.68 (5.78) | 84.15 (5.77) | 83.17 (5.92) | <0.001 |
| 70–74 years old, n (%) | 270 (11.61) | 287 (11.24) | 297 (10.41) | 292(10) | 279 (8.74) | 298 (8.45) | 242 (6.82) | 243 (6.33) | 254 (6.59) | 220 (5.64) | 2682 (8.25) | <0.001 |
| 75–79 years old, n (%) | 530 (22.79) | 584 (22.88) | 634 (22.23) | 582 (19.93) | 645 (20.21) | 667 (18.92) | 692 (19.51) | 710 (18.48) | 669 (17.37) | 600 (15.39) | 6313 (19.42) | |
| 80–84 years old, n (%) | 742 (31.9) | 775 (30.36) | 862 (30.22) | 879 (30.1) | 911 (28.54) | 1063 (30.16) | 1093 (30.82) | 1144 (29.78) | 1165 (30.24) | 1179 (30.24) | 9813 (30.19) | |
| ≥85 years old, n (%) | 784 (33.71) | 907 (35.53) | 1059 (37.13) | 1167 (39.97) | 1357 (42.51) | 1497 (42.47) | 1519 (42.84) | 1744 (45.4) | 1764 (45.79) | 1900 (48.73) | 13 698 (42.14) | |
| Charlson Comorbidity Index 1, n (%) | 638 (27.43) | 694 (27.18) | 776 (27.21) | 809 (27.71) | 854 (26.75) | 971 (27.55) | 934 (26.34) | 949 (24.71) | 998 (25.91) | 931 (23.88) | 8554 (26.32) | <0.001 |
| Charlson Comorbidity Index 2, n (%) | 1064 (45.74) | 1180 (46.22) | 1269 (44.5) | 1307 (44.76) | 1434 (44.92) | 1610 (45.67) | 1599 (45.09) | 1701 (44.29) | 1632 (42.37) | 1660 (42.58) | 14 456 (44.47) | |
| Charlson Comorbidity Index ≥3, n (%) | 624 (26.83) | 679 (26.6) | 807 (28.3) | 804 (27.53) | 904 (28.32) | 944 (26.78) | 1013 (28.57) | 1191 (31.01) | 1222 (31.72) | 1308 (33.55) | 9496 (29.21) | |
| Previous stroke | 1138 (48.93) | 1265 (49.55) | 1413 (49.54) | 1347 (46.13) | 1587 (49.72) | 1740 (49.36) | 1749 (49.32) | 1921 (50.01) | 1872 (48.6) | 1934 (49.6) | 15 966 (49.12) | 0.142 |
| Atrial fibrillation, n (%) | 594 (25.54) | 671 (26.28) | 747 (26.19) | 798 (27.33) | 880 (27.57) | 932 (26.44) | 920 (25.94) | 977 (25.44) | 1059 (27.49) | 1118 (28.67) | 8696 (26.75) | 0.045 |
| Hypertension, n (%) | 1237 (53.18) | 1429 (55.97) | 1643 (57.61) | 1672 (57.26) | 1871 (58.62) | 2106 (59.74) | 2077 (58.57) | 2159 (56.21) | 2180 (56.59) | 2177 (55.83) | 18 551 (57.07) | 0.000 |
| Malnutrition, n (%) | 41 (1.76) | 82 (3.21) | 105 (3.68) | 107 (3.66) | 123 (3.85) | 163 (4.62) | 126 (3.55) | 173 (4.5) | 167 (4.34) | 162 (4.15) | 1249 (3.84) | 0.000 |
| Pneumonia, n (%) | 342 (14.7) | 385 (15.08) | 420 (14.73) | 457 (15.65) | 529 (16.57) | 634 (17.99) | 584 (16.47) | 607 (15.8) | 631 (16.38) | 650 (16.67) | 5239 (16.12) | 0.011 |
| Urinary tract infection, n (%) | 518 (22.27) | 592 (23.19) | 720 (25.25) | 703 (24.08) | 814 (25.5) | 920 (26.1) | 879 (24.79) | 966 (25.15) | 971 (25.21) | 962 (24.67) | 8045 (24.75) | 0.044 |
| Agitation, n (%) | 4 (0.17) | 8 (0.31) | 4 (0.14) | 7 (0.24) | 12 (0.38) | 6 (0.17) | 9 (0.25) | 16 (0.42) | 9 (0.23) | 16 (0.41) | 91 (0.28) | 0.266 |
Analysis of the Spanish National Hospital Discharge Database from 2004 to 2013.
Charlson Comorbidity Index, excluding dementia and diabetes.
p Value for comparison by year.
Poisson regression model to assess trends in incidence rates, analysis of variance and Pearson'sχ2 for means and proportions respectively.
N, number of discharges.