Table 3.
Analysis of association between alleles & ADHD associated trait scores of male ADHD probands
Genes | Variants | Alleles | ‘T scores’ for cognitive problems / inattention | ‘T scores’ for hyperactivity | ‘T scores’ for ADHD index | DSM-IV scores for ODD trait | ||||
---|---|---|---|---|---|---|---|---|---|---|
Mean ± SE | p | Mean ± SE | p | Mean ± SE | p | Mean ± SE | p | |||
MAOA | 30 bp-uVNTR | 3R | 71.90 ± 1.03 | 0.26 | 75.16 ± 1.23 | 0.15 | 71.27 ± 0.83 | 0.29 | 14.75 ± 1.10 | 0.32 |
4R | 70.77 ± 1.37 | 72.93 ± 1.74 | 70.45 ± 1.19 | 15.68 ± 1.76 | ||||||
rs5906883 | A | 72.26 ± 1.01 | 0.11 | 75.34 ± 1.27 | 0.11 | 71.48 ± 0.84 | 0.17 | 14.42 ± 1.06 | 0.17 | |
C | 70.15 ± 1.42 | 72.70 ± 1.63 | 70.11 ± 1.16 | 16.32 ± 1.84 | ||||||
rs1465107 | G | 71.14 ± 1.47 | 0.37 | 72.74 ± 1.71 | 0.12 | 70.51 ± 1.21 | 0.31 | 16.11 ± 1.80 | 0.21 | |
A | 71.71 ± 1.00 | 75.22 ± 1.23 | 71.24 ± 0.83 | 14.53 ± 1.08 | ||||||
rs1465108 | A | 71.71 ± 1.00 | 0.37 | 75.22 ± 1.23 | 0.12 | 71.24 ± 0.83 | 0.31 | 14.53 ± 1.08 | 0.21 | |
G | 71.14 ± 1.47 | 72.74 ± 1.71 | 70.51 ± 1.21 | 16.11 ± 1.80 | ||||||
rs5905809 | C | 70.17 ± 1.37 | 0.12 | 72.24 ± 1.60 | 0.06 | 69.83 ± 1.13 | 0.10 | 16.21 ± 1.80 | 0.19 | |
G | 72.24 ± 1.03 | 75.58 ± 1.27 | 71.63 ± 0.85 | 14.47 ± 1.08 | ||||||
rs5906957 | A | 72.24 ± 1.03 | 0.12 | 75.58 ± 1.27 | 0.06 | 71.63 ± 0.85 | 0.10 | 14.47 ± 1.08 | 0.19 | |
G | 70.17 ± 1.37 | 72.24 ± 1.60 | 69.83 ± 1.13 | 16.21 ± 1.80 | ||||||
rs6323 | T | 69.48 ± 1.62 | 0.08 | 70.88 ± 2.12 | 0.02 | 69.00 ± 1.34 | 0.04 | 15.35 ± 2.11 | 0.43 | |
G | 72.20 ± 0.95 | 75.60 ± 1.12 | 71.67 ± 0.78 | 14.95 ± 1.02 | ||||||
rs1137070 | C | 70.35 ± 1.46 | 0.15 | 73.00 ± 1.66 | 0.15 | 70.22 ± 1.18 | 0.20 | 17.32 ± 1.77 | 0.04 | |
T | 72.15 ± 1.00 | 75.17 ± 1.26 | 71.42 ± 0.83 | 13.91 ± 1.07 | ||||||
MAOB | rs4824562 | A | 71.29 ± 0.95 | 0.29 | 73.79 ± 1.10 | 0.11 | 70.59 ± 0.77 | 0.12 | 14.88 ± 1.04 | 0.35 |
G | 72.44 ± 1.65 | 76.85 ± 2.41 | 72.59 ± 1.43 | 15.81 ± 2.20 | ||||||
rs56220155 | G | 72.08 ± 1.36 | 0.34 | 76.86 ± 1.81 | 0.07 | 72.67 ± 1.15 | 0.07 | 13.82 ± 1.40 | 0.21 | |
A | 71.31 ± 1.02 | 73.50 ± 1.19 | 70.38 ± 0.82 | 15.51 ± 1.17 | ||||||
rs2283728 | T | 72.25 ± 1.42 | 0.32 | 77.79 ± 1.63 | 0.04 | 73.04 ± 1.25 | 0.06 | 13.73 ± 1.57 | 0.25 | |
C | 71.33 ± 0.98 | 73.51 ± 1.18 | 70.45 ± 0.79 | 15.35 ± 1.09 | ||||||
rs2283727 | C | 71.33 ± 0.98 | 0.32 | 73.51 ± 1.18 | 0.04 | 70.45 ± 0.79 | 0.06 | 15.35 ± 1.09 | 0.25 | |
A | 72.25 ± 1.42 | 77.79 ± 1.63 | 73.04 ± 1.25 | 13.73 ± 1.57 | ||||||
rs3027441 | C | 74.31 ± 1.60 | 0.04 | 76.83 ± 1.58 | 0.10 | 73.72 ± 1.27 | 0.02 | 14.15 ± 1.74 | 0.34 | |
T | 70.74 ± 0.95 | 73.74 ± 1.20 | 70.23 ± 0.78 | 15.23 ± 1.07 | ||||||
rs6324 | C | 70.74 ± 0.95 | 0.04 | 73.74 ± 1.20 | 0.10 | 70.23 ± 0.78 | 0.02 | 15.23 ± 1.07 | 0.34 | |
T | 74.31 ± 1.60 | 76.83 ± 1.58 | 73.72 ± 1.27 | 14.15 ± 1.74 | ||||||
rs3027440 | T | 71.08 ± 0.90 | 0.12 | 73.77 ± 1.14 | 0.08 | 70.57 ± 0.76 | 0.08 | 14.90 ± 1.06 | 0.34 | |
C | 73.73 ± 2.00 | 77.64 ± 1.83 | 73.14 ± 1.45 | 16.00 ± 1.68 |
Statistically significant differences are presented in bold