Fig. 5.

mutUNG1-expressing mice fed a ketogenic diet. show a deranged distribution of mitochondria. (A) Quantification of the mitochondrial area in CA1 pyramidal cell somas from electron micrographs shows a significant increase in mitochondrial mass in mutUNG1-expressing mice fed a ketogenic diet (p = 0.02) and in mutUNG1-expressing mice fed a standard diet (p = 0.01), compared with wild-type mice fed a standard diet. (B) Quantification of the mitochondrial area in presynaptic terminals in the CA1 stratum radiatum from electron micrographs shows a significant decrease in mitochondrial mass in mutUNG1-expressing mice fed a ketogenic diet (p = 0.05), and in mutUNG1-expressing mice fed a standard diet (p = 0.03), compared with wild-type mice fed a standard diet. The data are presented as mean ± standard deviation; *p≤ 0.05; **p≤ 0.01. Abbreviation: KD, ketogenic diet.