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. 2017 Aug 19;88(10):869–875. doi: 10.1136/jnnp-2017-316174

Table 3.

Summary data of review of the literature of patients with TBK1 variants

No of patients (variants) Clinical presentation* M/F* Mean age at onset
±SD (years)*
ALS
(fALS)		 ALS-FTD FTD M+F M F
All 110
(80)		 57
(17)		 16 19 45/39 60.4
±10.9		 58.1
±11.3		 62.0
±10
LoF 59
(32)		 30
(13)		 10 12 30/24 62.5
±9.7		 61.0
±9.6		 64.3
±9.7

*For some patients reported data are not complete. Extensive data are presented in online supplementary table 4.

ALS, amyotrophic lateral sclerosis; F, female; fALS, familial ALS; FTD, frontotemporal dementia;  LoF, loss of function; M, male; TBK1, TANK-binding kinase 1.