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Simulation of AP with increasing dofetilide and vardenafil concentration for cardiomyocyte alone (A and B), cardiomyocyte coupled with one fibroblast (C and D) and cardiomyocyte coupled with three fibroblasts (E and F). Concentrations of dofetilide simulated are 0, 0.01, 0.1, 1 and 30 μM while simulated concentrations of vardenafil are 0, 0.01, 0.1, 1 and 30 mM.
