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. 2017 Aug 1;31(15):1561–1572. doi: 10.1101/gad.301648.117

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© 2017 Wilhelm et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — Inactivation of bec-1 extends life span through autophagy and is independent of classical longevity pathways. (A) bec-1 RNAi treatment shows no reduction in effect on MTL when combined with simultaneous ced-4 RNAi treatment at day 9 in rrf-3(pk1426) worms. qPCR validation is in Supplemental Table S12. (B) bec-1, vps-34, and epg-8 extend the MTL of rrf-3(pk1426) worms equally when inactivated at day 9. (C) Day 9 RNAi against bec-1 extends the MTL of glp-1(e2141) worms. (D) Day 9 RNAi against bec-1 extends the MTL of rrf-3(pk1426);daf-2(e1370) worms. (E) Combined inactivation of bec-1 and let-363(TOR) at day 9 in wild-type (N2) worms further extends their MTL compared with let-363 inactivation alone. qPCR validation is in Supplemental Table S12. Days represent days after first egg lay. Life span statistics are in Supplemental Tables 6 and 7.