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. 2017 Oct;27(10):1634–1644. doi: 10.1101/gr.225763.117

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© 2017 Lenain et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — Massive changes in genome–nuclear lamina interactions occur during OIS. (A) Experimental setup. The time points indicated in the brackets correspond to days after BRAF^V600E retroviral transduction or serum starvation. (B) Heat map representation of correlations of Dam-LMNB1 methylation ratios between the two biological replicates each for quiescent, cycling, and OIS cells. (C, i). Genome–NL interaction profile along Chromosome 6 for quiescent cells after 10 d of serum starvation, and cycling and OIS cells 10 d after retroviral transduction. The y-axis represents log₂ of Dam-LMNB1 over Dam-only methylation ratio. (ii) Changes in LMNB1 interaction in OIS cells for Chromosome 6. Some regions showing changes in NL interactions are highlighted in purple boxes.